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*Dermal thinning reference: Shuster et al., Br J Dermatol skins dermal thickness declines approximately 30% by age 65.
In a demyelination mouse model with neuroinflammation, KD treatment inhibits the activation of pro-inflammatory glial cells and decreases the production of pro-inflammatory cytokines, including IL-1 and TNF-, in addition to significantly reducing histone deacetylase 3 and NLRP3 (151)
Am J Physiol 239:R437-444 Khanna C, Boermans HJ, Wilcock B (1997) Fatal hypernatremia in a dog from salt ingestion
#### Contraindications: Known hypersensitivity to ascorbic acid or any of the excipients
