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Fu S, Naing A, Fu C, Kuo MT, Kurzrock R
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In endothelial cells, DMF upregulates glycolysis and diminishes cellular respiration (oxidative phosphorylation), while it downregulates the serine and glycine biosynthesis pathway by direct inhibition of phosphoglycerate dehydrogenase (PHGDH) activity by a yet unknown mechanism
Occult stage IIIA-N2 patients have excellent overall survival with initial surgery
