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Despite these promising results, MK-0493 did not show clinically significant efficacy in obese human participants at either a 400 mg PO dose or a step-titrated 800 mg PO dose ( ad libitum energy intake model, MK-0493 was associated with a small and marginally significant reduction in total 24-hour energy intake, whereas 30 mg of sibutramine (positive control) was associated with a significant reduction in total 24-hour energy intake ( While MK-0493 did not achieve clinical success, an analysis of these studies can provide potential rationale for failure

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On OCT, the overlying retinal pigment epithelium (RPE) showed slight irregularity, and the foveal photoreceptors appeared thickened and shaggy, implying relatively fresh subretinal fluid