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However, damage or error theories suggest that aging is the result of damage accumulation (i.e., ROS, DNA mutations, protein misfolding) in cells and tissues from cumulative environmental exposures over time (Jin, 2010)

(2) Preclinical-to-clinical translation: conducting phase I/II trials to validate efficacy, safety, and pharmacokinetic profiles of emerging platforms (e.g., artificial organelles and nanozymes)

Cells that did not undergo hypoxia remained in normoxia (20% O 2 ) for the same duration as their matched hypoxia counterparts

Patients with these conditions require careful evaluation by their provider before initiating therapy, as they may be at increased the risk for gastrointestinal adverse effects or complications