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3.3.1 Ferroptosis inducers Small molecules targeting iron metabolism: Erastin was first identified in 2003 as a genetically selective antitumor agent that induces ferroptosis primarily through interaction with VDACs (76, 120)

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Resistance to these drugs, the researchers showed, appears to be caused by increases in insulin, a hormone that regulates glucose and plays an important role in the development of diabetes

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