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Introduction The enzyme methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in the metabolism of folate and one-carbon transfer reactions, as well as in regulating homocysteine levels by reducing 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF), which serves as a donor of the methyl group for homocysteine to methionine conversion
