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Second, only a small subset of the total cellular pool of Akt needs to be active to achieve maximal substrate phosphorylation, as demonstrated in 3T3-L1 adipocytes and mouse muscle [24,30]

This is why, for example, short-acting benzodiazepines such as alprazolam and lorazepam are more difficult to discontinue than long-acting benzodiazepines such as diazepam and clonazepam