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Both Tesamorelin and AOD-9604 show preferential reduction of abdominal/visceral fat, but through different mechanisms

10.1097/MOH.0b013e32831ac517 44 NizetV

GDF8, expressed predominantly in skeletal muscle, is cleaved by all TLDs and preferentially by TLL2 due to the availability of this TLD in the muscle, while the ubiquitously expressed GDF11 is cleaved preferentially by BMP1 and TLL1 [6]
