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In contrast, cytotoxicity was detectable when cells were treated with BSO first then washed and treatment with HCH followed (Fig

Among different classes, Phi and Tau class GSTs are plant-specific and predominantly present, whereas the smaller Theta and Zeta classes, having restricted xenobiotic activity, are also found in animals

43,44 Circulating levels of insulin are proportional to adiposity, as with leptin

The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases