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Impairment of these degradation systems is thought to contribute to the accumulation of -synuclein in the body [16]

The ability of FPM to effectively guide care is reliant on the quality of each model, and here, we have identified several key aspects necessary for a clinically informative model, including the establishment rate of tumors within each model, the time to establish tumors and perform the required assays, cost, genetic fidelity, the ability of each model to capture the diverse tumor environment, and whether each model can provide an assessment of off-target toxicity