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Furthermore, as with the use of the combination of anti-CTLA-4 and anti-PD-1 or anti-PD-L1, the frequency and severity of irAEs were higher than with single immune checkpoint inhibitor monoclonal antibody treatment

(72) reported in a randomized controlled trial that the Yiqi Yangyin Huoxue formula combined with acupuncture lowered IL-1, IL-17, and serum amyloid A (SAA) levels, and improved blood glucose and renal function, indicating a synergistic effect with core acupoints such as ST36, SP6, and BL23

NAC infusions have been widely used in acute hepatic failure but convincing evidence of its benefits is lacking

Mitochondria require GSH to maintain redox balance, yet GSH is made exclusively in the cytosol