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10.1038/s41419-023-05672-9 Cell Death Dis
2018;47:439452 e6
Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, et al

however, about two-thirds of NP patients report poor pain control [142], which necessitates the repeated and prolonged use of opioids and higher doses to alleviate pain, such that various side effects caused by opioids cannot be avoided
