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While it was not possible to derive a mechanism of lung toxicity for LPS from this dataset, for most of the other benchmark chemicals, this analysis was able to provide further insights into their putative mechanism of toxicity

Ozone Peroxides as Second Messenger Molecules Autoxidation is not to be confused with ozonolysis (Figure 3b): whereas ozone reacts with isolated double bonds in a highly selective manner, this is not or far less the case with polyunsaturated fatty acids, i.e., especially conjugated double bonds

Genetic factors, including mutations in SNCA, LRRK2, and VPS35, promote -synuclein aggregation into Lewy bodies and neurites

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