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17 Genetic variants of PKLR have shown to be associated with acute pain in patients with SCD 25 and, together with the expected metabolic effects, provide a potential rationale for the use of PK activators as a therapeutic strategy in SCD

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Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice

A double blind, randomized clinical trial