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Cell 156 (1-2), 317331
The report recommends that EPA provide risk estimates using both nonlinear and linear methods to extrapolate below PODs
The decrease in the therapeutic effect of opioids can be explained by the commonality of the downregulation of opioid receptors in both the PNS and/or CNS under NP status and the long-term, repeated use of opioids (Figure 1)
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