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Since this pathway use NADPH as electron donor, this compromises the availability of this coenzyme to regenerate reduced glutathione, exacerbating the oxidative stress [189]

Natural compounds such as metformin and resveratrol display the ability to mimic the effects of caloric restriction, acting on stress response and metabolic pathways (Ingram et al., 2006)

97 Although 8-oxoG can be repaired by the 8-oxoguanine DNA glycosylase 1-mediated base excision repair pathway, it continues to accumulate during aging and disease progression

Williams is seated in her purple velvet chair, now in the living room of her Manhattan apartment