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Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors

The respiratory region, which forms the largest part of the nasal cavity, is highly vascularised, allowing drugs deposited there to be rapidly absorbed into the systemic circulation and potentially reach the brain after crossing the BBB (Jeong et al., 2023)

Lower right panel : comparison of scopolamine with atropine, emphasizing greater CNS penetration and effects of scopolamine at therapeutic doses, including sedation and memory impairment, versus the relatively limited CNS activity of atropine, which is more associated with restlessness and confusion at higher doses
