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Similarly, in the context of diabetes, GPx1 / ApoE / mice had augmented atherosclerosis with increased macrophage infiltration, increased nitrotyrosine levels, and increased expression of proinflammatory and profibrotic markers in mouse aorta [79]

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ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation

This is akin to what happens in Graves disease, an autoimmune disorder where the bodys immune system mistakenly attacks the thyroid gland, leading to a cascade of health issues including rapid heartbeat, weight loss, and nervousness
