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Introduction Reactive oxygen and nitrogen species are generated by endogenous and exogenous processes, while enzymatic and non-enzymatic antioxidants neutralize them

Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ (1996) Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

doi: 10.1016/j.acthis.2017.01.010

These findings elucidated the multilevel regulatory consequences of ACE2KO and provided mechanistic insights into associated metabolic dysfunction