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[1] Those who cannot digest or absorb B12 as a result of inherited genetics or damage to the stomach and small intestine require more than can be absorbed from sublingual supplementation

Genetic tools are less effective in manipulating and visualizing non-proteinaceous cellular structures such as lipids and glycans, but non-genetic approaches are challenging due to the low permeability and unusual architecture of the mycobacterial envelope

Health status creates absolute contraindications for treatment

Chung B, Segrest J, Smith K, Griffin F, Brouillette C
