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Food Science and Biotechnology

Dysregulation of KEAP1-NRF2 activity has been extensively demonstrated in cellular and animal models of ALS and in postmortem ALS motor cortex and spinal cord samples, so dysregulation of the NRF2/ARE antioxidant and cytoprotective pathway could be a possible mechanism underlying the progressive neurodegeneration in ALS and severity of the disease

On the other hand, synthetic antioxidants (Fig

The liver contains the highest concentration of these enzymes, which is consistent with its primary function as receptor of the majority of the xenobiotics absorbed by the organism
