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The four primary underlying mechanisms can be summarised as follows (Figure 6: First, radiotherapy can upregulate the expression ofataxiatelangiectasia mutated (ATM) gene and further inhibit the transport function of system XCthrough inducing DNA double strand breaks (DBSs), which leads to the inhibition of antioxidant activity of GSH and GPX4, therebyresulting in lipid peroxidation ( FIGURE 6 Regarding the application of ferroptosis in radiotherapy, the combination of radiotherapy and the ferroptosis inducer (FIN) was found to act synergistically in tumour treatment by increasing lipid peroxidation and upregulating PTGS2 expression, with FINS exerting significant radio-sensitising effects in vitro and in vivo ( , leading to GSH depletion ( in vivo , resulting in the improved efficacy of radiotherapy and inhibition of tumour growth ( Furthermore, a study reported that ferroptosis was also involved in radiotherapy-induced cellular damage in normal cells instead of only affecting tumour cells ( Combined Application of Ferroptosis and Photodynamic Therapy Photodynamic therapy (PDT) is a non-invasive cancer treatment modality

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For many, taking an oral supplement may be the best way to ensure adequate intake, it is easy and does not require a lot of effort and time in our busy lifestyles.

(Life Extension is still often more expensive than Nature Made, however.) Nature Made is also a great option for those who prefer gummy supplements over swallowing pills