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investigated the combined effects of hydrocaffeic, dihydroxyphenylacetic and hydroferulic acid metabolites from colon microbiota and found that these polyphenols can reduce the synthesis of prostaglandin E2 in IL-1-stimulated CCD-18 colon fibroblast cells [177]

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Core Writing TeamLeeH.RomeroJ

1.3.1 Cytoplasmic hybrid (cybrid) cell lines First derived in 1975 by Wallace, Bunn, and Eisenstadt, cytoplasmic hybrid (cybrid) cell lines are generated by the fusing of nucleated cells that have had their endogenous mtDNA depleted via exposure to ethidium bromide with enucleated cells (cytoplasts), which harbor the mtDNA signature of interest (Figure 3A