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World J Stem Cells

The model is also consistent with published results that show that female mice are less susceptible than males to hepatotoxicity due to acetaminophen overdose and suggests that this might also be true for humans, though the human epidemiological data are contradictory

By regulating energy balance through AMPK activation and mitochondrial signaling, it offers potential benefits for metabolic health, fat loss, endurance, recovery, and aging

263,264 JNK and p38 signaling also play essential roles in MAPK cascade, they can triggered by various damages mainly activated by MKK4/7 and MKK3/6 kinases, respectively