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Glutathione peroxidase (GPX) catalyzes the reduction of hydroperoxides, including hydrogen peroxides, by reduced glutathione and functions to protect the cell from oxidative damage

Injured patients initially presented with fever and gastrointestinal disorders after ingestion of a single large dose or long-term small doses, and over 29 weeks symptoms worsened with hemolysis, cholestatic hepatitis and disseminated intravascular coagulopathy

10.1113/EP091162 147 RawalG.YadavS.KumarR

It catalyses the transfer of electrons from GSH to disulfides (Holmgren, 1989), which maintains the intracellular redox homeostasis in the face of oxidative stress (Jung and Thomas, 1996)