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The density indicates some flexibility at R471 in both the inward-facing and ipratropium-bound structures, but both are pointing down towards the extracellular side and wedged between S157 and S467, preventing the H-bond network we observe in the occluded conformation (Fig

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So far, so good

There is a report showing that EPA alone increases mitochondrial fatty acid oxidation, while DHA increases peroxisomal fatty acid oxidation 22
