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Clinical and animal studies have demonstrated that a major physiological consequence of total parenteral nutrition is the loss of intestinal barrier integrity.52 Mice administrated with total parenteral nutrition show increased intestinal paracellular permeability and decreased levels of TJ proteins, which is reversed by IL-10 treatment.53 Collectively, IL-10 restores the intestinal barrier defect

If we are looking to optimize absorption, it is better to take the oral supplement on an empty stomach or between meals than after a meal, as the fraction absorbed is greater

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