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110 Moreover, CDDP-resistant cancer cells may exhibit increased levels of GSH, the enzyme that catalyzes GSH synthesis (i.e., -glutamylcysteine synthetase), the enzyme that conjugates CDDP with GSH (i.e., glutathione S-transferase), or metallothioneins

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

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Importantly, CHAC2 did not localize to the mitochondria irrespective of extracellular cystine availability, further suggesting divergent roles for these proteins in mediating intracellular GSH catabolism