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demonstrated that disruption of overall Wnt activity through either directly inhibiting ligand binding or halting Wnt ligand diffusion results in a disorientation of hair cell bundles, indicating that secreted Wnt proteins are required for correct PCP in the cochlea (Dabdoub et al., Wnt7a is expressed in the developing cochlear duct and cochlear explants cultured in Wnt7a conditioned medium resulted in misalignment of hair cell bundles

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