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The B12 component remains the same regardless of indication

Previous studies showed that both experimentally induced circulating IGF-1 deficiency [14] and cell-specific disruption of IGF1R signaling in astrocytes [42] impair astrocyte-mediated NVC responses

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Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation
