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Furthermore, the replacement of Cys with SeCys at the metal binding site increase bond due to larger atomic radii of Se potentially affecting its interaction with the co-factors ( 3 2- ) and glutathione (GSH) generates superoxide radicals (O 2 - ), resulting in the subsequent accumulation of hydrogen peroxide (H 2 O 2 )
Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency
Two single nucleotide polymorphisms of CAT gene, viz., 1167T/C and -262C/T, have been reported to have a strong association with type 1 diabetes mellitus [36]
V.KriwackiR
