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However, the clinical application of nanotechnology delivery systems for nose-to-brain drug delivery is in the early stages of development

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A distinct subtype is the **plexiform neurofibroma**, often linked to neurofibromatosis type 1 (NF1)

Although MPNSTs can be roughly assessed by imaging and immunohistochemistry in clinical practice, more precise criteria are still needed for more detailed classification and grading of MPNSTs