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Ferroportin mediates intracellular iron output to maintain the dynamic balance of iron, and excess iron will remain intracellular as ferritin
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Furthermore, increased HSP90 and the decreased GPX4 levels were detected in subcutaneous xenograft tumors after Tim-AIII administration, which further confirmed HSP90 and GPX4 were the main players involved in the anticancer effects triggered by Tim-AIII
