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(iv) Augmented diacylglycerol (DAG) synthesis followed by PKC activation, which are linked to NOX activation, reduced insulin-stimulated NO production [100], upregulated expression of adhesion molecules, increased endothelin-1 (ET-1) release [101], and p66Shc activation [102,103]

903 Iron-chelating agents inhibit osteoclast bone resorption and prevent bone loss due to ovariectomy

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Under normal conditions, there is a well-regulated equilibrium in the GI mucosa between inflammatory cytokines (such as TNF-, IL-1, IL-6, IL-8, IL-17, and IL-23) and anti-inflammatory cytokines (like IL-5, IL-10, IL-11, and TGF-) (75)