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Description
2020;6(3):eaay6324

CDK4/6 inhibitors combined with targeted therapy The PI3K-AKT-mTOR pathway proteins and the CDK-Rb-E2F pathway proteins are widely co-expressed in different tumor types, and the two pathways are the relationship between the upstream and downstream, signifying that the combined targeting inhibition of CDK4/6 and PI3K-AKT-mTOR should further improve the efficacy [59]

Further research confirmed that CENPT was a key component in the assembly of the kinetochore protein complex, which was essential for normal mitotic progression

Genet 24 , 109132 (2023)