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The findings were published in the American Journal of Psychiatry on Wednesday and are sure to raise questions about the merits of swapping one of these substances for another, especially given growing concern in the public health field about the popularity of cannabis

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Current treatment options include approved drugs such as serotonin-norepinephrine reuptake inhibitors, e.g., duloxetine, gabapentinoids such as pregabalin and gabapentin, topical treatment with capsaicin, and several off-label use drugs such as other antidepressants (e.g., tricyclic antidepressants), antiepileptic drugs, and weak and strong opioids