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Description
The broad pH range employed in assays is explained by the fact that typically an excess of HRP is used with respect to the amount of oxidase activity
The first case, also discovered by the same research group, was a female who carried the pathological PSEN1-E280A mutation as well as two copies of the protective APOE3 Christchurch ( APOECh
doi: 10.1128/JVI.80.6.3021-3029.2006
Protein purification was performed as mentioned above
