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Description
Elevated circulating TMAO levels have been associated with decreased expression of sirtuin 1 (SIRT1), leading to increased oxidative stress

Ethics declarations Ethics approval and consent to participate The study protocol was approved by the Independent Bioethics Committee for Scientific Research at the Medical University of Gdansk (NKBBN/354 201/2017)

Disturbance in the metabolism and homeostasis of main inhibitory and excitatory neurotransmitters, glutamate and GABA, are important pathogenic pathways

CPT II deficiency can be suspected by acylcarnitine analysis in blood, revealing a typical profile with accumulation of long-chain species [5]
