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(PubMed) Almeida OP, Marsh K, Alfonso H, Flicker L, Davis TM, Hankey GJ

B12 supplements often don't help and may even hurt people with sickle cell anemia, Wright says

It is recommended to administer subcutaneously during the morning on an empty stomach
Examples of higher-evidence options Semaglutide (injectable) and tirzepatide (injectable) are two prescription medications with large, high-quality human trials showing substantial average weight loss