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389,390 Moreover, improvements in CRISPR-Cas9 technology present opportunities for accurate genetic and epigenetic alterations to rectify inherited genetic variants and epigenetic markers associated with DPN

After receiving the patients informed consent, we began the following treatment in July 2019: Combined therapy with oral antioxidants propolis 700 mg + bilberry 180 mg + silymarin 400 mg + ginkgo biloba 240 mg + L-carnitine 1000 mg + coenzyme Q10 100 mg + Boswellia 200 mg + vitamin E 48 mg + vitamin C 50 mg + superoxide dismutase 11,000 IU/g 10 mg/daily + topical diclofenac gel 4%/2 daily + peri-plaque penile injection of pentoxifylline 100 mg with 30 G needle every month for 12 months

Pooyandjoo et al

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