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127 SFAs, such as palmitic acid, can increase the production of ceramide and NO, leading to impaired insulin synthesis, and the apoptosis of cells through inflammation, ERS, and oxidative stress, which can be blocked by unsaturated fatty acids

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Dissociation between sensing and metabolism of glucose in sugar sensing neurones

These include 3 : Damaging proteins and cell membranes , interfering with normal cellular function
