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In addition, Glu has the following features: chemical stability, metabolic generation and easy removal (interconversion with -ketoglutarate), negative charge (at physiological pH value), and acidic amino acid [due to its two carboxyl groups (- and -carboxyl) and one amino group]

For untreated control cells, the cell membrane was intact (Fig

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However, in the presence of 20% human plasma, a 100-fold rightward curve shift was observed for the lipidated compounds, but not the conjugates and the GLP-1 analogue, indicating that MK-801 and inactive MK-801 do not associate strongly with HSA (Fig