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For instance, angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs are used as an effective first-line therapy

doi: 10.1007/978-3-031-72467-1_8 64 DhruvaS

This antioxidant effect also enhances the activity of direct-acting antivirals such as telaprevir, especially in telaprevir-resistant replicon cells ( Beyond HCV, PYC also modulates host factors implicated in viral replication and immune regulation, including long non-coding IFN-induced protein-44 (lnc-IFI-44), polycystic kidney disease 1-like 3 (Pkd1l3), and ubiquitin-specific peptidase 31 (Usp31) ( PYC has also been reported to inhibit HIV-1 entry and replication ( Importantly, PYCs antiviral activity extends beyond direct viral inhibition to include complementary host-directed effects

Challenges in this area include the need for comprehensive multi-omics approaches to capture the complexity of gut microbial communities and T-cell populations, as well as the integration of large-scale omics data with clinical phenotypes to identify predictive biomarkers of disease progression and treatment response