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Clusters 2, 4, and 5 were identified as profibrotic lipid-associated macrophages (LAMs) because of high expression of profibrotic genes (Fn1, Spp1, CD44) and lipid metabolism genes (Lpl, Trem2, Fabp4, Fabp5)
This may be related to the findings that high levels of ROS can mitigate metastasis and tumorigenesis, for example in cancer cells detaching from the extracellular matrix [42,43]
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