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Description
These observations suggest an altered fatty acid synthesis and -oxidation in mouse retinas lacking IGF-1R

thus, inhibitors of this enzyme could have clinical importance
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Furthermore, FXR transcriptionally activates Acsl4 in intestinal epithelial cells (IECs), promoting ferroptosis and subsequently impairing ILC3 function, and can induce Wnt2b in cancer-associated fibroblasts (CAFs) within the tumor stroma, fostering a pro-tumorigenic niche (92, 93)
