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The lipid peroxides formed may be chemotactic for the neutrophils causing increased inflammation, which further drives oxidant-mediated injury in the liver
The heterodimeric complex of dual oxidase (DUOX, EC:1.6.3.1) and its maturation factor, DUOXA2, generates the required H 2 O 2 in a NADPH-dependent reaction maintained by the pentose phosphate cycle [48]
Roginsky, V
