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Next, using oligodendrocyte and APOE4-expressing oligodendrocyte cultures, they found that APOE4 in oligodendrocytes contributes to cellular cholesterol accumulation and diminished fluorescence intensity of MBP [78]

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In DN, 1) renal biopsy samples show downregulated SLC7A11 (System Xc subunit) and GPX4, with reduced GSH and elevated lipid peroxides under high glucose (HG) (124, 126)

To avoid crosstalk with native gene networks, researchers have incorporated orthogonal elements, regulatory sequences and TFs derived from fungi, bacteria, or viruses, which respond to plant-like cues but function independently from endogenous pathways