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doi: 10.1095/biolreprod.110.085712
Rapamycins efficacy is further limited due to its metabolism via cytochrome P450 3A4 (Cyp3A4), which is induced by rifampin, complicating its use alongside standard TB treatments
Litifilimab, a novel anti-BDCA-2 antibody, has been shown to decrease the interferon secretion of plasmacytoid dendritic cells and could reduce the articular involvement in SLE patients compared to placebo in a multicenter, phase 2 trial (ClinicalTrials.gov Identifiers: NCT05352919 and NCT05531565, respectively)
