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This insight has guided Fc-engineering of IgG variants with improved pH-dependent FcRn binding, resulting in antibodies with extended plasma half-life in human FcRn transgenic mice, non-human primates (NHPs) as well as humans 10,23,24,25
The cytoskeleton-associated tight junction was enhanced (Fig
J Glob Health
[DOI] [PubMed] [Google Scholar] 39.Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn GW, 2nd, Trimarco B, Iaccarino G
