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Method: Sprague Dawley rats weighing 200-250 grams were used for the study

A serum blank experiment to detect any interfering peaks in the HPLC chromatogram was performed by in an identical manner except that no drug was added

It is possible that in addition to potential over activation of Keap 1 or lack of Keap1 turnover, Nrf2 in neutrophils is post-translationally modified in periodontitis patients, which might interfere with its ability to undergo nuclear trafficking

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